首页>
外国专利>
Cerium Oxide Nanoparticles for Treatment and Prevention of Alzheimer's Disease, Parkinson's Disease, and Disorders Associated with Free Radical Production and/or Mitochondrial Dysfunction
Cerium Oxide Nanoparticles for Treatment and Prevention of Alzheimer's Disease, Parkinson's Disease, and Disorders Associated with Free Radical Production and/or Mitochondrial Dysfunction
Cerium oxide nanoparticles (CeONP) can be used to treat or prevent neurodegenerative diseases, including for example Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, AIDS-related dementia, ALS, progressive supranuclear palsy, and encephalitis, as well as mitochondrial diseases and diseases associated with mitochondrial damage. In particular, CeONP having an average size of about 2 nm to about 100 nm can be administered in an amount sufficient to block production of hydroxyl or superoxide radicals, block free radical production by Aβ(1-42), block Aβ(1-42)-induced neuronal death, block Aβ(1-42)-induced [Ca2+]i dysfunction in neurons, block Aβ(1-42)-induced lipid peroxidation, decrease loss of dopaminergic neurotransmission, or reduce mitochondrial dysfunction in a cell. CeONP can also be effective in treating conditions involving toxic exposures to compounds that induce mitochondrial dysfunction, such as rotenone, cyanide, carbon monoxide, polychlorinated biphenyls (PCBs) and other mitochondrial toxins.
展开▼
机译：氧化铈纳米粒子（CeONP）可用于治疗或预防神经退行性疾病，包括例如阿尔茨海默氏病，帕金森氏病，亨廷顿氏病，与艾滋病有关的痴呆症，ALS，进行性核上性麻痹和脑炎，以及线粒体疾病和相关疾病线粒体受损。特别地，可以以足以阻止羟基或超氧化物自由基产生，通过Aβ（1-42）阻止自由基产生的量施用平均尺寸为约2nm至约100nm的CeONP。 ，阻断Aβ（1-42）诱导的神经元死亡，阻断Aβ（1-42）诱导的[Ca 2 + ] i 在神经元中的功能障碍，阻断Aβ（1-42）引起的脂质过氧化，减少多巴胺能神经传递的损失，或减少细胞中的线粒体功能障碍。 CeONP还可有效治疗涉及毒性引起线粒体功能障碍的化合物（如鱼藤酮，氰化物，一氧化碳，多氯联苯（PCB）和其他线粒体毒素）的暴露状况。
展开▼
