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PROLONGED DELIVERY OF HEPARIN-BINDING GROWTH FACTORS FROM HEPARIN-DERIVATIZED COLLAGEN

机译:从肝素衍生的胶原蛋白中延长结合肝素的生长因子

摘要

The present invention relates to a heparin-derivatized collagen matrix comprising a fragment of heparin covalently linked to a collagen scaffold, wherein the fragment of heparin has molecular weight of less than about 15 kDa, and at least one heparin-binding growth factor (HBGF) or heparin-binding adeno-associated virus (HB-AAV) or a combination thereof and methods for promoting bone growth, bone repair, cartilage repair, bone development, neo-angiogensis, wound healing, tissue engraftment and muscle tissue regeneration and/or tissue augmentation comprising administering a heparin-derivatized collagen matrix that includes at least one heparin-binding growth factor or heparin-binding adeno-associated virus or a combination thereof.
机译:本发明涉及一种肝素衍生的胶原蛋白基质,其包含与胶原蛋白支架共价连接的肝素片段,其中所述肝素片段的分子量小于约15kDa,并且至少一种肝素结合生长因子(HBGF)或肝素结合腺相关病毒(HB-AAV)或其组合,以及用于促进骨骼生长,骨骼修复,软骨修复,骨骼发育,新血管生成,伤口愈合,组织植入和肌肉组织再生和/或组织的方法增强包括给予肝素衍生的胶原蛋白基质,所述胶原蛋白基质包括至少一种肝素结合生长因子或肝素结合腺相关病毒或其组合。

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