首页> 外国专利> SCREENING METHOD FOR COMPOUND INHIBITING DEVELOPMENT OR PROGRESSION OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS AND DIAGNOSTIC METHOD FOR FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS

SCREENING METHOD FOR COMPOUND INHIBITING DEVELOPMENT OR PROGRESSION OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS AND DIAGNOSTIC METHOD FOR FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS

机译：复合抑制家族性肌萎缩侧索硬化症的发展的筛选方法和诊断家族性肌萎缩侧索硬化症的诊断方法

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摘要

A screening method comprising the following steps is provided.A step of culturing cells in the presence and in the absence of a test compound,a step of measuring HIF-1α expression in the respective cultured cells, anda step of determining the test compound to be a compound that inhibits onset or progression of familial amyotrophic lateral sclerosis if the HIF-1α expression in the cells cultured in the presence of the test compound is less than the HIF-1α expression in the cells cultured in the absence of the test compound.

机译：提供了一种包括以下步骤的筛选方法。在有和没有测试化合物的情况下培养细胞的步骤，测量HIF-1α表达的步骤确定受试化合物是否是抑制家族性肌萎缩性侧索硬化症（如果HIF发生或进展）的化合物的步骤在没有受试化合物的情况下培养的细胞中-1α的表达低于在没有受试化合物的情况下培养的细胞中的HIF-1α的表达。

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公开/公告号US2009269794A1

专利类型
公开/公告日2009-10-29

原文格式PDF
申请/专利权人 AKIRA NAKAGAWARA;KEIZO TAKENAGA;SHIGENOBU MOCHIZUKI;
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申请/专利号US20060063347
发明设计人 AKIRA NAKAGAWARA;KEIZO TAKENAGA;SHIGENOBU MOCHIZUKI;
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申请日2006-08-09
分类号C12Q1/02;
国家 US
入库时间 2022-08-21 19:34:42

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