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FXR Agonists for the Treatment of Nonalcoholic Fatty Liver and Cholesterol Gallstone Diseases

机译:FXR激动剂用于治疗非酒精性脂肪肝和胆固醇胆结石疾病

摘要

Provided are certain methods of treating nonalcoholic fatty liver disease with farnesoid X receptor agonists. Also provided are certain methods of modulating levels of keratinocyte-derived chemokine (KC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), cytokeratin 18 (CK-18), matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-14 (MMP-14), tissue inhibitor of metalloproteinase 1 (TIMP-1), and Cytochrome P450 2E1 (CYP2E1); certain methods of identifying FXR modulators; and certain methods of treating patients with existing cholesterol gallstone disease.
机译:提供了使用法呢类X受体激动剂治疗非酒精性脂肪肝疾病的某些方法。还提供了某些调节角质形成细胞衍生趋化因子(KC),丙氨酸氨基转移酶(ALT),天冬氨酸氨基转移酶(AST),细胞角蛋白18(CK-18),基质金属蛋白酶9(MMP-9),基质金属蛋白酶-水平的方法14(MMP-14),金属蛋白酶1(TIMP-1)和细胞色素P450 2E1(CYP2E1)的组织抑制剂;识别FXR调制器的某些方法;和某些治疗胆固醇胆固醇结石病患者的方法。

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