首页> 外国专利> NEW COMPOUND, METHOD FOR PRODUCING NEW COMPOUND BY UTILIZING NEW BIOSYNTHETIC ROUTE OF MENAQUINONE, METHOD FOR INCREASING QUANTITY OF PRODUCTION OF MENAQUINONE BY UTILIZING INTERMEDIATE IN NEW BIOSYNTHETIC ROUTE OF MENAQUINONE, AND METHOD FOR SEARCHING INHIBITOR SPECIFIC TO NEW BIOSYNTHETIC ROUTE OF MENAQUINONE BY UTILIZING INTERMEDIATE IN NEW SYNTHETIC ROUTE OF MENAQUINONE

NEW COMPOUND, METHOD FOR PRODUCING NEW COMPOUND BY UTILIZING NEW BIOSYNTHETIC ROUTE OF MENAQUINONE, METHOD FOR INCREASING QUANTITY OF PRODUCTION OF MENAQUINONE BY UTILIZING INTERMEDIATE IN NEW BIOSYNTHETIC ROUTE OF MENAQUINONE, AND METHOD FOR SEARCHING INHIBITOR SPECIFIC TO NEW BIOSYNTHETIC ROUTE OF MENAQUINONE BY UTILIZING INTERMEDIATE IN NEW SYNTHETIC ROUTE OF MENAQUINONE

机译：新化合物，利用美甲醌的新生物合成路线生产新化合物的方法，利用美甲醌的新生物合成路线中的中间体提高甲萘醌产量的方法以及通过对药味的信息进行人工合成的方法甲萘醌的新合成路线

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PROBLEM TO BE SOLVED: To provide a new compound constituting a new biosynthetic route of menaquinone, a method for producing the new compound by utilizing the route, a method for increasing the quantity of production of the menaquinone by utilizing the compound, and a method for searching an inhibitor specific to the route.;SOLUTION: A specific compound is provided. The method for producing the compound includes reacting futalosine with an enzyme for carrying out de-hypoxanthine of the futalosine or a recombinant enzyme having activity for carrying out the de-hypoxanthine of the futalosine, and a reducing agent in the presence of water or a buffer solution. The method for producing the new compound includes making an orthologous gene-broken strain of a microorganism having a new synthetic route of the menaquinone, and culturing the broken strain in the presence of the menaquinone. A method for searching an inhibitor by synthesizing a structural analogue of the compound, adding the material to a microorganism having the new biosynthetic route of the menaquinone, and identifying the structural analogue as the inhibitor specific to the new biosynthetic route of the menaquinone from proliferation-inhibiting activity of the microorganisms and inhibitory activity against the enzyme carrying out the de-hypoxanthine of the futalosine.;COPYRIGHT: (C)2009,JPO&INPIT

机译：解决的问题：提供构成新的甲萘醌生物合成路线的新化合物，利用该路线生产该新化合物的方法，一种利用该化合物增加甲萘醌产量的方法以及用于该方法的方法。搜索特定于该途径的抑制剂。;解决方案：提供了一种特定的化合物。化合物的制造方法包括将他他洛辛与用于进行他他洛辛的去次黄嘌呤的酶或具有对他他洛辛的去次黄嘌呤具有活性的重组酶与还原剂在水或缓冲液的存在下反应。解。生产新化合物的方法包括制备具有新的甲萘醌合成路线的微生物的直系同源基因断裂菌株，以及在甲萘醌存在下培养该断裂菌株。一种通过合成化合物的结构类似物，将物质添加到具有新的甲基萘醌生物合成途径的微生物中，并从增殖作用中识别结构类似物为甲基萘醌新生物合成途径特异性抑制剂的方法来搜索抑制剂。氟他洛辛的去氧次黄嘌呤对微生物的抑制活性和对酶的抑制活性。;版权所有：（C）2009，日本特许厅

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公开/公告号JP2009114124A

专利类型
公开/公告日2009-05-28

原文格式PDF
申请/专利权人 ADEKA CORP;
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申请/专利号JP20070289063
发明设计人 OTOSHI TORU;SETO HARUO;FURUHATA KAZUO;YAMASHITA HARUYUKI;
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申请日2007-11-06
分类号C07H7/04;C12Q1/02;C12N15/09;C12P7/42;C12R1/465;C12R1/01;
国家 JP
入库时间 2022-08-21 19:43:00

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