首页> 外国专利> New Phenylthiazolyl/phenyloxazolyl derivatives are peroxisome proliferator-activated receptor agonist useful to treat e.g. diabetic, dyslipidemia, cardiovascular disease, hypertension, inflammatory diseases and cerebral ischaemia

New Phenylthiazolyl/phenyloxazolyl derivatives are peroxisome proliferator-activated receptor agonist useful to treat e.g. diabetic, dyslipidemia, cardiovascular disease, hypertension, inflammatory diseases and cerebral ischaemia

机译：新的苯基噻唑基/苯并恶唑基衍生物是过氧化物酶体增殖物激活的受体激动剂，可用于治疗例如环孢霉素。糖尿病，血脂异常，心血管疾病，高血压，炎性疾病和脑缺血

页面导航

摘要
著录项
相似文献

摘要

Phenylthiazolyl/phenyloxazolyl derivatives (I) and their stereoisomeres (diastereoisomers, enantiomers), racemic mixtures, geometrical isomers, tautomers, salts, hydrates, solvates, solid forms or their mixtures are new. Phenylthiazolyl/phenyloxazolyl derivatives of formula (I) and their stereoisomeres (diastereoisomers, enantiomers), racemic mixtures, geometrical isomers, tautomers, salts, hydrates, solvates, solid forms or their mixtures are new. X1halo, R1, -SR1 or -OR1; X2R2; X3halo, R3, -SR3 or -OR3; X4halo, R4, -SR4 or -OR4; X5R5, -SR5 or -OR5; X6R6, -SR6 or -OR6; X7R7, -SR7 or -OR7; X8S or O; R1, R3, R4, R6, R7 = H or alkyl; R2H or alkyl (optionally substituted by (hetero)cycloalkyl or (hetero)aryl); R5alkyl substituted by -COOR12, -CONR12R13, -SO3H or -SO2NR12R13, where substitutents are substituted by optionally substituted by (hetero)cycloalkyl or (hetero)aryl; A : CO, C=N-O-H, C=N-O-R11, -CR9R10 or R11; R9, R10H, alkyl or -OR11; R11H, aryl, heterocycloalkyl, heteroaryl or alkyl (optionally substituted by (hetero)cycloalkyl or (hetero)aryl); B12C alkyl (unsubstituted, saturated) or 2C alkene (unsubstituted); and R12, R13H or alkyl (unsubstituted). An independent claim is included for a pharmaceutical composition comprising (I), in a support, optionally in combination with therapeutic and/or cosmetic active ingredients and a compound. [Image] ACTIVITY : Analgesic; Antianginal; Antidiabetic; Antilipemic; Cardiovascular-Gen; Anorectic; Hypotensive; Antiinflammatory; Cerebroprotective; Vasotropic; Immunosuppressive; Cytostatic; Neuroprotective. MECHANISM OF ACTION : Peroxisome proliferator-activated receptor agonist.

机译：苯基噻唑基/苯基恶唑基衍生物（I）及其立体异构体（非对映异构体，对映异构体），外消旋混合物，几何异构体，互变异构体，盐，水合物，溶剂化物，固体形式或它们的混合物是新的。式（I）的苯基噻唑基/苯基恶唑基衍生物及其立体异构体（非对映异构体，对映异构体），外消旋混合物，几何异构体，互变异构体，盐，水合物，溶剂化物，固体形式或其混合物是新的。 X1halo，R1，-SR1或-OR1; X2R2; X3halo，R3，-SR3或-OR3; X4halo，R4，-SR4或-OR4; X5R5，-SR5或-OR5; X6R6，-SR6或-OR6; X7R7，-SR7或-OR7; X8S或O; R1，R3，R4，R6，R7 ＝ H或烷基; R 2 H或烷基（任选地被（杂）环烷基或（杂）芳基取代）;被-COOR12，-CONR12R13，-SO3H或-SO2NR12R13取代的R5烷基，其中取代基被任选地被（杂）环烷基或（杂）芳基取代的取代基; A：CO，C ＝ N-O-H，C ＝ N-O-R11，-CR9R10或R11; R9，R10H，烷基或-OR11; R11H，芳基，杂环烷基，杂芳基或烷基（任选地被（杂）环烷基或（杂）芳基取代）; B12C烷基（未取代的，饱和的）或2C烯烃（未取代的）; R12，R13H或烷基（未取代）。包括对药物组合物的独立权利要求，所述药物组合物包含在载体中的（I），任选地与治疗和/或美容活性成分和化合物组合。 [图片]活动：止痛药;抗心绞痛抗糖尿病抗血脂;心血管基因厌食的;降压;消炎（药;脑保护变压性免疫抑制细胞抑制具有神经保护作用。作用机理：过氧化物酶体增殖物激活的受体激动剂。

著录项

公开/公告号FR2910893A1

专利类型
公开/公告日2008-07-04

原文格式PDF
申请/专利权人 GENFIT SOCIETE ANONYME;
展开▼

申请/专利号FR20060056065
发明设计人 DELHOMEL JEAN FRANCOIS;
展开▼

申请日2006-12-29
分类号C07D277/24;A61K31/426;A61P3;
国家 FR
入库时间 2022-08-21 19:47:04

相似文献

专利
外文文献
中文文献