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USE OF CORE-SHELL GOLD NANOPARTICLE WHICH CONTAINS MAGNETIC NANOPARTICLES FOR MRI T2 CONTRAST AGENT, CANCER DIAGNOTICS AND THERAPY
USE OF CORE-SHELL GOLD NANOPARTICLE WHICH CONTAINS MAGNETIC NANOPARTICLES FOR MRI T2 CONTRAST AGENT, CANCER DIAGNOTICS AND THERAPY
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机译：含有磁性纳米粒子的核壳金纳米粒子在MRI T2造影剂，癌症诊断和治疗中的应用
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摘要
A core-shell gold nanoparticle containing magnetic nanoparticles is provided to improve image clearness of MRI(magnetic resonance image) as MRI T2 contrast agent, and efficiency of cancer diagnosis, and rapidly kill the cancer cells by using laser pulse, so that diagnosis and treatment of cancer are performed simultaneously. A core-shell gold nanoparticle contains a silica core having diameter of 50-500 nm and a gold nanoshell having diameter of 50-500 nm with magnetic nanoparticles having diameter of 2-30 nm which contains polyalkylene glycol on the surface of nanoparticles and a target-directing ligand linked to the polyalkylene glycol, wherein the magnetic nanoparticle is selected from magnetite(Fe3O4), maghemite(gamma-Fe3O4), cobalt ferrite(CoFe2O4), manganese oxide(MnO), manganese ferrite(MnFe2O4), ion-platinum alloy, cobalt-platinum alloy and coba the target-directing ligand is selected from anti-HER2/neu, folate, aptamer and TAT peptide.
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