首页> 外国专利> USE OF CORE-SHELL GOLD NANOPARTICLE WHICH CONTAINS MAGNETIC NANOPARTICLES FOR MRI T2 CONTRAST AGENT, CANCER DIAGNOSTIC AND THERAPY

USE OF CORE-SHELL GOLD NANOPARTICLE WHICH CONTAINS MAGNETIC NANOPARTICLES FOR MRI T2 CONTRAST AGENT, CANCER DIAGNOSTIC AND THERAPY

机译：包含磁性纳米粒子的核壳金纳米粒子在MRI T2造影剂，癌症诊断和治疗中的应用

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摘要

The present invention relates to the use of magnetic gold nanoshells consisted of gold nanoshells embedded with magnetic nanoparticles and spherical silica cores for use in MRI T2 contrast agent, cancer diagnosis and cancer therapy. More particularly, the present invention is directed to the use of an MRI T2 contrast agent using the magnetic properties of the magnetic nanoparticles embedded with the gold nanoshell, a cancer diagnostic agent for treating cancer using the cancer binding properties of target-specific ligands bonded to the surface of the magnetic gold nanoparticles and a therapeutic agent for treating cancer using the heat released form the gold nanoshell absorbed from the energy of near infrared ray range electromagnetic pulses to destroy the cancer cells, and methods for the diagnosis and treatment of cancer using the magnetic gold nanoparticles.

机译：本发明涉及磁性金纳米壳的用途，该磁性金纳米壳由嵌入有磁性纳米颗粒和球形二氧化硅核的金纳米壳组成，用于MRI T2造影剂，癌症诊断和癌症治疗。更具体地，本发明涉及利用嵌入有金纳米壳的磁性纳米颗粒的磁性来使用MRI T2造影剂的方法，所述MRI是利用结合至靶标的配体的癌症结合特性来治疗癌症的癌症诊断剂。磁性金纳米颗粒的表面和利用释放出的热量形成的癌症治疗剂形成了从近红外线范围电磁脉冲的能量吸收的金纳米壳，从而破坏了癌细胞，以及使用该方法诊断和治疗癌症的方法磁性金纳米粒子。

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公开/公告号WO2008048074A1

专利类型
公开/公告日2008-04-24

原文格式PDF
申请/专利权人 SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION;HYEON TAEGHWAN;KIM JAE YOON;CHO MYUNG-HAING;KIM SEONG KEUN;LEE JUNGHEE;
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申请/专利号WO2007KR05154
发明设计人 HYEON TAEGHWAN;KIM JAE YOON;CHO MYUNG-HAING;KIM SEONG KEUN;LEE JUNGHEE;
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申请日2007-10-19
分类号A61K49/06;A61P43;
国家 WO
入库时间 2022-08-21 19:59:50

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