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Fluorescence polarization-based method for analysis of Farnesoid X Receptor-ligand complex interaction and for screening inhibitors against the Farnesoid X Receptor-ligand complex binding
Fluorescence polarization-based method for analysis of Farnesoid X Receptor-ligand complex interaction and for screening inhibitors against the Farnesoid X Receptor-ligand complex binding
The present invention relates to a method for analyzing the interaction of a panesoid X receptor-ligand complex using fluorescence polarization and a method for screening binding inhibitors, and specifically, between a panesoid X receptor (FXR) and a fluorescently labeled ligand using fluorescence polarization. Interaction analysis method and binding inhibitory candidates were added to samples containing fluorescently labeled ligands and Panesoid X receptors, and fluorescent fluorescence was measured to confirm competitive binding of ligands to inhibitors of binding to Panesoid X receptors. The present invention relates to a method for screening a binding inhibitor of a panesoid X receptor and a ligand complex. The interaction analysis method and binding inhibitor search method of the present invention can be effectively applied to the ultra-fast search using the well plate is very useful for the development of hyperlipidemia therapeutics.;Panesoid X Receptor, Fluorescence Polarization, Ligand
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