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IDENTIFICATION AND USE OF SMALL MOLECULES TO MODULATE ESE-1 TRANSCRIPTION FACTOR FUNCTION AND TO TREAT ESE-1 TRANSCRIPTION FACTOR ASSOCIATED DISEASES
IDENTIFICATION AND USE OF SMALL MOLECULES TO MODULATE ESE-1 TRANSCRIPTION FACTOR FUNCTION AND TO TREAT ESE-1 TRANSCRIPTION FACTOR ASSOCIATED DISEASES
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机译:鉴定和使用小分子调节ESE-1转录因子功能并治疗ESE-1转录因子相关疾病
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摘要
The present invention relates to methods of identifying small molecule candidate agents capable of modulating transcription factor function such that the function/expression of a target transcription factor and/or proteins downstream of this target protein comprises the screening of small molecule libraries using in silico high throughput docking for candidate small molecules/agents that are selectively identified for their ability to target and disrupt the transcription factor-DNA interface through unique transcription factor and/or DNA descriptors that are defined within a pharmacophore, and then testing/evaluating the candidate agents identified above through one or more in vitro assays for their ability to modulate transcription factor function including expression of this target protein and/or proteins that are downstream of the target transcription factor.
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