• 主题
高级搜索  >
历史搜索 清空历史
首页> 外国专利> Recombinant DNA sequences encoding feedback inhibition released enzymes, plasmids comprising the recombinant DNA sequences, transformed microorganisms useful in the production of aromatic amino acids, and a process for preparing aromatic amino acids by fermentation

Recombinant DNA sequences encoding feedback inhibition released enzymes, plasmids comprising the recombinant DNA sequences, transformed microorganisms useful in the production of aromatic amino acids, and a process for preparing aromatic amino acids by fermentation

机译：编码反馈抑制释放的酶的重组DNA序列，包含重组DNA序列的质粒，可用于生产芳香族氨基酸的转化微生物以及通过发酵制备芳香族氨基酸的方法

页面导航
  • 摘要
  • 著录项
  • 相似文献

摘要

A method for releasing feedback inhibition of the key enzymes in the production of aromatic amino acids by fermentation is disclosed. Aromatic amino acids are prepared by a process which comprises transforming a microorganism with a recombinant ONA sequence bearing a gene or gene group encoding a feedback inhibition-released enzyme in the phenylalanine and/or tryptophan biosynthetic pathway, obtained by substituting one or two amino acid residue(s) or deleting one or more amino acid residue(s) of 3-deoxy-D-arabinoheptulonic acid 7-phosphate synthase (DS) or prephenate dehydratase, culturing the microorganism and isolating the aromatic amino acid produced in the medium. Higher efficiency and improved yields in the production of L-phenylalanine and L-tryptophan by fermentation are realized.
机译：公开了通过发酵释放在芳香族氨基酸生产中关键酶的反馈抑制的方法。芳香族氨基酸是通过以下方法制备的，该方法包括用重组ONA序列转化微生物，所述ONA序列在苯丙氨酸和/或色氨酸生物合成途径中带有编码反馈抑制释放酶的基因或基因组，该基因或基因组通过取代一个或两个氨基酸残基获得。或缺失3-脱氧-D-阿拉伯庚基庚酸7-磷酸合酶（DS）或苯甲酸酯脱水酶的一个或多个氨基酸残基，培养微生物并分离培养基中产生的芳香族氨基酸。通过发酵生产L-苯丙氨酸和L-色氨酸实现了更高的效率和提高的产量。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号