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首页> 外国专利> METHODS, COMPOSITIONS AND DEVICES, INCLUDING MICROFLUIDIC DEVICES, COMPRISING COATED HYDROPHOBIC SURFACES

METHODS, COMPOSITIONS AND DEVICES, INCLUDING MICROFLUIDIC DEVICES, COMPRISING COATED HYDROPHOBIC SURFACES

机译：方法，组成和设备，包括微流体设备，包括涂层的疏水表面

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Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating layer and the hydrophobic surface is not required. Subsequent layers may then interact chemically or non-chemically with at least a portion of the first coating layer and/or region. Such coated surfaces may be part of a device or apparatus, including microfluidic devices. Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include a substrate having at least one microchannel, a cover arranged on a surface of the microchannel, and at least one electrical potential source. Some embodiments include a microchannel widened at an outlet. Other embodiments position the electrical potential source along a surface of the cover. Still other embodiments include a well in which an electrode and a membrane are disposed. The various embodiments provide stable electrospray ionization of substances from a microfluidic device to a mass spectrometer.
机译：公开了涂覆至少一部分疏水性表面的方法，所述疏水性表面包括塑料或其他聚合物的表面。这样的方法包括使用第一涂层和/或与疏水表面相互作用的区域，尽管不需要在第一涂层和疏水表面之间形成化学键。随后的层然后可以与第一涂层和/或区域的至少一部分化学或非化学地相互作用。这样的涂覆表面可以是包括微流体装置的装置或设备的一部分。微流体装置将物质提供给质谱仪。所述微流体装置包括具有至少一个微通道的基底，布置在所述微通道的表面上的盖以及至少一个电势源。一些实施例包括在出口处加宽的微通道。其他实施例将电势源沿着盖的表面定位。其他实施例包括其中布置有电极和膜的孔。各种实施例提供了从微流体装置到质谱仪的稳定的电喷雾物质电离。

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