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首页> 外文会议>2017 32nd Symposium on Microelectronics Technology and Devices >Parylene-C film as hydrophobic surface in glasses microfluidic devices for double emulsions
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Parylene-C film as hydrophobic surface in glasses microfluidic devices for double emulsions

机译：聚对二甲苯-C膜在玻璃微流体装置中作为疏水性表面用于双乳

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摘要

Double-emulsions are an important strategy to encapsulate drugs and pharmaceutical ingredients. In this way microfluidic devices have offered a successful tool to produce controlled size droplets with high homogeneity. In spite of many advantages of the use of microfluidic devices to produce double emulsions, these devices require two different surface characteristics on the same device. In this work we present the use of Parylene-C, a polymeric film obtained by chemical vapor deposition, as a hydrophobic surface over a hydrophilic substrate. Parylene-C deposition occurs under room temperature. A mechanical mask can be used to protect regions of interest. The deposition renders a 2-5 μm of Parylene-C film inside a device that have microchannels with depths of 87μm. The regions covered with Parylene-C offered a contact angle of 105° and with a conformal deposition. The microfluidic device was used to produce water-in-oil-in water double emulsion and was possible to encapsulate B12 vitamin inside an oil droplet. This work is still in progress, and adjustments on the solutions concentrations used must be pursued. However, the use of Parylene-C presents a promising technique to produce microfluidic devices useful for double emulsions.
机译：双乳剂是封装药物和药物成分的重要策略。以此方式，微流体装置提供了成功的工具，以产生具有高均质性的可控制尺寸的液滴。尽管使用微流体装置产生双重乳液具有许多优点，但是这些装置在同一装置上需要两个不同的表面特性。在这项工作中，我们介绍了通过化学气相沉积获得的聚合物薄膜Parylene-C作为亲水性基材上的疏水性表面的用途。聚对二甲苯-C沉积在室温下发生。机械掩模可用于保护感兴趣区域。沉积在具有微通道深度为87μm的设备内形成2-5μm的Parylene-C膜。聚对二甲苯-C覆盖的区域提供了105°的接触角和保形沉积。该微流体装置用于生产水包油包水型双乳液，并且可以将B12维生素包封在油滴内。这项工作仍在进行中，必须对使用的溶液浓度进行调整。然而，使用对二甲苯-C提出了一种有前途的技术来生产可用于双重乳液的微流体装置。

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