首页> 外国专利> PROCEDURE FOR MANUFACTURE OF SYNTHETIC OXYGEN VEHICLES FROM COVALENTLY RETICULATED HEMOGLOBINS WITH FUNCTIONAL PROPERTIES IMPROVED BY RETICULATION IN THE PRESENCE OF EFFECTS THAT DO NOT CHEMICALLY REACT THE OXYGEN BODY AFFINITY.

PROCEDURE FOR MANUFACTURE OF SYNTHETIC OXYGEN VEHICLES FROM COVALENTLY RETICULATED HEMOGLOBINS WITH FUNCTIONAL PROPERTIES IMPROVED BY RETICULATION IN THE PRESENCE OF EFFECTS THAT DO NOT CHEMICALLY REACT THE OXYGEN BODY AFFINITY.

机译:在没有化学反应氧亲和力的情况下,通过网化改善功能功能的均价网状血球制造合成氧车辆的方法。

摘要

A process for the production of synthetic oxygen vehicles by means of a bifunctional protein crosslinking agent, selected from butadiene diepoxide, divinylsulfone, a diisocyanate, especially hexamethylene diisocyanate, cyclohexyl diisocyanate and 2,5-bisisocyanatobenzenesulfonic acid, a di- N-hydroxysuccinimidyl ester, a diimidoester, or a dialdehyde, especially glyoxal, the glycoaldehyde that reacts analogously; or hemoglobin chemically crosslinked with glutardialdehyde with improved functional properties, characterized in that prior to covalent crosslinking of hemoglobin, effectors are added that do not chemically react from the oxygen affinity of hemoglobin selected from 2,3-bisphosphoglycerate, inositol hexaphosphate, Inositol hexasulfate or melitic acid at its reaction solution.
机译:通过双官能蛋白质交联剂生产合成氧载体的方法,所述双官能蛋白质交联剂选自丁二烯二环氧化物,二乙烯基砜,二异氰酸酯,尤其是六亚甲基二异氰酸酯,环己基二异氰酸酯和2,5-双异氰酸根合苯磺酸,二-N-羟基琥珀酰亚胺酯,二亚氨基酯,或二醛,特别是乙二醛,类似地反应的糖醛;或与戊二醛化学交联的血红蛋白具有改善的功能特性,其特征在于在血红蛋白共价交联之前,添加了不会与选自2,3-双磷酸甘油酸,肌醇六磷酸,肌醇六硫酸盐或me胶的血红蛋白的氧亲和力发生化学反应的效应子酸在其反应溶液中。

著录项

  • 公开/公告号ES2284670T3

    专利类型

  • 公开/公告日2007-11-16

    原文格式PDF

  • 申请/专利权人 SANGUIBIOTECH GMBH;

    申请/专利号ES20010957822T

  • 发明设计人 BARNIKOL WOLFGANG;

    申请日2001-06-02

  • 分类号A61K35/14;A61K38/42;A61P43;

  • 国家 ES

  • 入库时间 2022-08-21 20:04:27

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