首页> 外国专利> Salts and formulations of 2 - hydroxy - n, N - dimethyl - 3 - 2 - 1 - (R) - 5 - methyl - 2 - furanil) propyl amino - 3.4 - - 1 - - dioxi cyclobutene 1 - il amino benzamide as either CXCR2 receptor Selective antagonist or both CXCR1 and CXCR2

Salts and formulations of 2 - hydroxy - n, N - dimethyl - 3 - 2 - 1 - (R) - 5 - methyl - 2 - furanil) propyl amino - 3.4 - - 1 - - dioxi cyclobutene 1 - il amino benzamide as either CXCR2 receptor Selective antagonist or both CXCR1 and CXCR2

机译：2-羟基-n，N-二甲基-3-[[[2-[1-（R）-5-甲基-2-呋喃腈）丙基]氨基]-3.4--1--二氧环丁烯1-的盐和制剂[il]个氨基]苯甲酰胺作为CXCR2受体选择性拮抗剂或同时用作CXCR1和CXCR2

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摘要

Refers to a Pharmaceutical composition comprising 2-hydroxy - n, N - dimethyl - 3 - [[2 - [1 - (R) - 5 - methyl - 2 - furanil) propyl] amino] - 3.4 - dioxi cyclobutene - 1 - 1 - il] amino] - benzamide (Compound i) or a Salt thereof and a pharmaceutically acceptable excipient.Within the excipients are Wetting agents such as Poloxamer is present in a proportion compared with the compound (i) between 0.3 to 1.2: 1: 1; Binding agents such as povidone, which is present in a proportion of the compound (i) A1: 1, 0.188: 1; agents and Solvents such as microcrystalline Cellulose crospovidone Lactose and disintegrating agents such as. This Compound is one of the selective antagonist of receptor CXCR2 CXCR1 or or both and is useful in the treatment of inflammatory diseases

机译：指包含2-羟基-n，N-二甲基-3-[[[2-[1-（R）-5-甲基-2-呋喃腈）丙基]氨基]-3.4-二氧环丁烯-1-1的药物组合物-il]氨基]-苯甲酰胺（化合物i）或其盐和药学上可接受的赋形剂。在赋形剂中，润湿剂如泊洛沙姆与化合物（i）的比例为0.3至1.2：1：1 ;诸如聚维酮的粘合剂，其以化合物（i）A1：1、0.188：1，剂和溶剂，例如微晶纤维素crospovidone乳糖和崩解剂，例如。该化合物是受体CXCR2 CXCR1或两者的选择性拮抗剂之一，可用于治疗炎症

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公开/公告号PE03682008A1

专利类型
公开/公告日2008-05-16

原文格式PDF
申请/专利权人 SCHERING CORPORATION;
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申请/专利号PE20070000740
发明设计人 KOU JIM H.;EICHMAN JONATHAN D.;
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申请日2007-06-12
分类号A61K31/341;A61P29/00;
国家 PE
入库时间 2022-08-21 20:06:34

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