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Targeting an allergen to the MHC class II processing and presentation pathway in a vaccination group induces a strong Th1 immune response
Targeting an allergen to the MHC class II processing and presentation pathway in a vaccination group induces a strong Th1 immune response
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机译:在疫苗接种组中将过敏原靶向II类MHC加工和呈递途径可诱导强烈的Th1免疫反应
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摘要
Recombinant nucleic acids encoding an allergen, a signal peptide which directs the translocation of the allergen to the endoplasmic reticulum, and preferably a second signal peptide targeting the gene product to an endosome or lysosome. When administered the recombinant nucleic acid induces Th1 type immunity and inhibits IgE production. Used in the treatment and prevention of allergic reactions.
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