首页> 外国专利> A PROCESS FOR THE SOLID STATE SYNTHESIS OF ENANTIOPURE ß-AMINOALCOHOLS FROM RACEMIC EPOXIDES

A PROCESS FOR THE SOLID STATE SYNTHESIS OF ENANTIOPURE ß-AMINOALCOHOLS FROM RACEMIC EPOXIDES

机译:消旋态固态合成对映体β-氨基醇的过程

摘要

The present invention relates to a process for the solid state synthesis of enantiopure β -aminoalcohols from racemic epoxides. The process relates to a process for the solid state synthesis of enantiopure β-aminoalcohols from racemic epoxides by the dynamic kinetic resolution involving enantiodifferentiating recemisation in crystalline cyclodextrin complexes. The invention discloses a process for the solid state synthesis of enantiopure β-aminoalcohols from racemic epoxides by dynamic kinetic resolution involving enantiodifferentiating racemisation n crystalline cyclodextrin complexes, which comprises synthesis of various racemic aryloxyepoxides to obtain their inclusion complex with cyclodextrins, reacting the epoxide of the cyclodextrin complex with amines under solid state conditions, extracting the product with solvent, removing the solvent and amine in cacuo and purifying the product β-aminoalcohol by the formation of hydrochloride.
机译:对映体的固态合成方法本发明涉及对映体的固态合成方法。 -来自外消旋环氧化物的氨基醇。该方法涉及通过动态动力学拆分由外消旋环氧化物固态合成对映纯-氨基醇的方法,该动力学动力学拆分涉及在结晶环糊精络合物中对映体差复性。本发明公开了一种通过动态动力学拆分从外消旋环氧化物固态合成对映体纯的氨基醇的方法,该动力学动力学拆分涉及对映体消旋外消旋的n个结晶环糊精配合物,该方法包括合成各种外消旋芳基环氧氧化物以使其与环糊精包合,然后与环糊精反应。在固态条件下将环糊精与胺进行环氧化,用溶剂萃取产物,在真空下除去溶剂和胺,并通过形成盐酸盐纯化产物-氨基醇。

著录项

  • 公开/公告号IN213222B

    专利类型

  • 公开/公告日2008-01-04

    原文格式PDF

  • 申请/专利权人

    申请/专利号IN127/DEL/2000

  • 申请日2000-02-16

  • 分类号C12P13/00;

  • 国家 IN

  • 入库时间 2022-08-21 20:07:15

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