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Process for the solid state synthesis of enantiopure B-aminoalcohols from racemic epoxides
Process for the solid state synthesis of enantiopure B-aminoalcohols from racemic epoxides
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机译:由外消旋环氧化物固态合成对映体纯的B-氨基醇的方法
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摘要
The invention relates to a process for the solid state synthesis of enantiopure &bgr;-aminoalcohols by preparing inclusion complexes of aryloxyepoxide with cyclodextrin by adding an epoxide in equimolar ratio in an organic solvent to an aqueous solution of cyclodextrin, reacting the cyclodextrin complex of aryloxyepoxide with a nucleophile in solid state by intimately grinding the mixture using a mortar and pestle, continuing the mixing till the starting epoxide disappeared on tic, removing excess amines under vacuum, extracting the &bgr;-aminoalcohols produced with a solvent with yields of more than 50% and enantioselectivity of upto 100%.
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