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Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I

机译:氯吡格雷碱的快速拆分工艺及硫酸氢氯吡格雷多晶型I的制备方法

摘要

The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer of clopidogrel base. The invention further discloses an improved process for preparation of acid addition salts of clopidogrel.
机译:本发明公开了外消旋氯吡格雷碱的快速拆分方法,然后将拆分的(S)异构体转化为结晶的硫酸氢氯吡格雷晶型I。本发明还公开了氯吡格雷碱的不需要的(R)异构体的新型消旋方法。本发明进一步公开了一种制备氯吡格雷的酸加成盐的改进方法。

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