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MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof

机译： MEN1 ，与多发性内分泌肿瘤1型，menin多肽有关的基因及其用途

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摘要

The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy. 展开▼

机译：本发明涉及与多发性内分泌肿瘤1型有关的新型肿瘤抑制基因的发现。该基因被命名为MEN1，基因产物是menin。在患有多发性内分泌肿瘤1型的个体中已经鉴定出该蛋白质的缺失和相关基因中的相关突变。针对多发性内分泌肿瘤1型的该标志物的鉴定具有诊断用途以及用于基因治疗。展开▼

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公开/公告号US7358347B1

专利类型

公开/公告日2008-04-15

原文格式PDF

申请/专利权人 SETTARA CHANDRASEKHARAPPA;SIRADANAHALLI GURU;PACHIAPPAN MANICKAM;FRANCIS S. COLLINS;MICHAEL R. EMMERT-BUCK;LARISA V. DEBELENKO;IRINA A. LUBENSKY;LANCE A. LIOTTA;SUNITA K. AGARWAL;ALLEN M. SPIEGEL;A. LEE BURNS;STEPHEN J. MARX;ZHENGPING ZHUANG;
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申请/专利号US19980380337

发明设计人 PACHIAPPAN MANICKAM;LARISA V. DEBELENKO;SETTARA CHANDRASEKHARAPPA;FRANCIS S. COLLINS;SIRADANAHALLI GURU;A. LEE BURNS;ALLEN M. SPIEGEL;IRINA A. LUBENSKY;SUNITA K. AGARWAL;LANCE A. LIOTTA;STEPHEN J. MARX;ZHENGPING ZHUANG;MICHAEL R. EMMERT-BUCK;
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申请日1998-03-04

分类号C07H21/00;C07H21/02;C07H21/04;C12Q1/68;C12P19/26;C12P19/34;

国家 US

入库时间 2022-08-21 20:11:22

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