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Method for culturing CD4-positive T cells by stimulation culture of HIV-1-infected peripheral blood mononuclear cells, and HIV-1 growth inhibitor
Method for culturing CD4-positive T cells by stimulation culture of HIV-1-infected peripheral blood mononuclear cells, and HIV-1 growth inhibitor
(Problem) CD4 positive T collected from AIDS patients infected with R5 HIV-1 using CCR5 as a co-receptor, X4 HIV-1 using CXCR4, and R5 / X4 HIV-1 using both CCR5 and CXCR4 A method for stably culturing and proliferating cells is provided. (Solution) An HIV-1 growth inhibitor containing a compound of the following formula 1 or a salt thereof, and culturing HIV-1-infected peripheral blood mononuclear cells using the inhibitor, CD4 A method for culturing positive T cells. V-CR1R2-Ar-CR3R4-N (R5)-(CR6R7) x-R8 (I) wherein V is a 9-24 membered cyclic polyamine moiety having 2-6 amine nitrogens, The amine nitrogens are spaced apart from each other by at least two carbon atoms; each of R1 to R7 independently consists of a hydrogen atom or a straight, branched or cyclic C1-6 alkyl A group selected from the group; and R8 is a monocyclic or polycyclic heterocyclic group, or a monocyclic or polycyclic group.
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