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Urinary sediment and / or urine mRNA ratio that is a prognostic marker and / or a terranostic marker for prostate cancer
Urinary sediment and / or urine mRNA ratio that is a prognostic marker and / or a terranostic marker for prostate cancer
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机译：尿沉渣和/或尿液mRNA比值是前列腺癌的预后标志和/或地形学标志
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摘要
Described herein are methods and kits for prognosis of prostate cancer in a subject. The methods comprises: (a) determining the ratio of PCA3 and PSA expression in a urine sample and (b) correlating the value of the PCA3/PSA ratio with the aggressiveness and mortality risk of prostate cancer in the subject. Kits for prognosing prostate cancer are also described. More particularly, the present invention features a method for prognosing prostate cancer in a biological sample of a patient comprising: assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of PSA in the biological sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of PSA; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value.
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