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Conjugates with enhanced cellular uptake activity

机译:与增强的细胞摄取活性结合

摘要

This invention relates to a conjugate molecule comprising at least one first portion (I) comprising a carrier sequence and at least one second portion (II) comprising at lest one anti-tumot drug molecule or a protease inhibitor molecule, said conjugate molecule comprising D-enantiomeric amino acids in its portion (I). Furthermore, the invention relates to pharmaceutical compositions containing said conjugate molecule as well as to the use of said conjugate molecule for therapeutical treatment. Methods for improving cell permeability are disclosed as well.
机译:本发明涉及缀合物分子,其包含至少一个包含载体序列的第一部分(I)和至少包含至少一个抗肿瘤药物分子或蛋白酶抑制剂分子的第二部分(II),所述缀合物分子包含D- (I)部分的对映体氨基酸。此外,本发明涉及包含所述缀合物分子的药物组合物以及所述缀合物分子在治疗中的用途。还公开了用于提高细胞渗透性的方法。

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