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METHOD FOR IMPROVING DISSOLUTION IN PHARMACEUTICAL PREPARATION AND PHARMACEUTICAL PREPARATION HAVING IMPROVED DISSOLUTION PROPERTY
METHOD FOR IMPROVING DISSOLUTION IN PHARMACEUTICAL PREPARATION AND PHARMACEUTICAL PREPARATION HAVING IMPROVED DISSOLUTION PROPERTY
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机译:改善药物制剂中溶解度的方法和具有改善的溶解性质的药物制剂
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摘要
PROBLEM TO BE SOLVED: To provide a method for improving the dissolution delay of an active component in a pharmaceutical preparation having an enteric polymer coating layer.;SOLUTION: The invention provides a method for improving the dissolution of an active component in a pharmaceutical preparation having an enteric polymer coating layer by using an alkaline pH-adjusting agent and a pharmaceutical preparation containing (1) a compound having interaction with an enteric polymer and (2) an alkaline pH-adjusting agent. Examples of the alkaline pH-adjusting agent is sodium bicarbonate, potassium bicarbonate, magnesium carbonate and sodium hydroxide, etc.;COPYRIGHT: (C)2008,JPO&INPIT
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