• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Conference on Functionalized and Sensing Materials >Spray-dried pectic polysaccharide powders: Evaluation of physicochemical properties for pharmaceutical preparations
【24h】

Spray-dried pectic polysaccharide powders: Evaluation of physicochemical properties for pharmaceutical preparations

机译：喷雾干燥的果糖粉末：药物制剂的物理化学性质评价

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pectic polysaccharide from durian rinds (Durio Zibethinus) has been reported to mainly compose of pectin which is generally used in various pharmaceutical dosage forms. The purpose of this research was to investigate the physicochemical properties of spray-dried pectic polysaccharide powders as a function of spray drying conditions (inlet temperature, feed rate, and aspirator rate) and formulation parameters (pectic polysaccharide concentration). A mini spray dryer was used to spray dry pectic polysaccharide in formulation with maltodextrin, colloidal silica and propylene glycol. Production yields were obtained between 31.08 - 52.87%. Higher yield percentage was obtained when the inlet temperature was increased. Particle size of < 7μm was from low pectic polysaccharide concentration. The pectic polysaccharide powders were bulky and the shape was almost spherical with smooth surface but collapsed at high inlet temperature and low feed rate. At 75% RH and room temperature, the powders could adsorb moisture of about 12% of the powder weight. The swelling index and mucoadhesion time that the powders attached to the porcine intestine was ranged 14 - 70 and 7 - >30 minutes, respectively. This research provides useful information for development of pectic polysaccharide as fine powder for drug delivery.
机译：据报道，来自榴莲外皮（DURIO ZIBETHINUS）的果糖，主要是果胶组成，该果胶通常以各种药物剂型使用。本研究的目的是研究喷雾干燥的果糖粉末作为喷雾干燥条件（入口温度，进料速率和吸气速率）和配制参数（PECTIC多糖浓度）的函数的物理化学性质。使用麦芽糖糊精，胶体二氧化硅和丙二醇的配方中使用迷你喷雾干燥器来喷射干燥的果糖。在31.08-52.87％之间获得产量。当入口温度升高时，获得较高的产率百分比。 <7μm的粒径来自低果糖浓度。果实多糖粉末膨胀，形状几乎是球形的，具有光滑的表面，但在高入口温度下塌陷，进给速率低。在75％RH和室温下，粉末可以吸附约12％的粉末重量的水分。膨胀指数和粘膜粘附时间分别附着在猪肠的粉末分别为14-70和7 - > 30分钟。本研究提供了有用的果糖作为药物递送的细粉末的发育。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号