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Efficient catalysts for the asymmetric epoxidation of electron deficient as well as non electron deficient alkenes

机译:用于缺电子和非缺电子烯烃的不对称环氧化的高效催化剂

摘要

A compound of formula I and its enantiomeric counterpart V; a process for the preparation of diol I, and alternatively diol V, comprising a) the acetylation of diol II, or respectively diol VI, with an acetylating agent, wherein said acetylation is performed in the presence of a Lewis acid and b) an aqueous work-up of the reaction mixture; and a method for producing an enantiomerically enriched epoxide from an alkene, said method comprising admixing said alkene, a substantially enantiomerically pure chiral diol selected from the group comprising diol I and diol V and an oxidizing agent. The method can further comprise the addition of a phase-transfer catalyst.
机译:式I化合物及其对映体对应物V;制备二醇I和二醇V的方法,其包括a)用乙酰化剂对二醇II或分别对二醇VI进行乙酰化,其中所述乙酰化在路易斯酸存在下进行,并且b)反应混合物的后处理;以及由烯烃生产对映体富集的环氧化物的方法,所述方法包括将所述烯烃,选自二醇I和二醇V的基本上对映体纯的手性二醇与氧化剂混合。该方法可以进一步包括添加相转移催化剂。

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