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Process for preparing salts of 4 - 5 - (ciclopropilamino) carbonyl - 2-methylphenyl amino - 5 - methyl - N - propilpirrolo 2,1-f 1,2 triazin - 6 - carboxamide and stable forms produced in this novel
Process for preparing salts of 4 - 5 - (ciclopropilamino) carbonyl - 2-methylphenyl amino - 5 - methyl - N - propilpirrolo 2,1-f 1,2 triazin - 6 - carboxamide and stable forms produced in this novel
Refers to salts of Crystalline form, such as the N - 1 of the hydrochloric acid salt in the base 4 - [[5 - [(ciclopropilamino) carbonyl] - 2-methylphenyl] amino] - 5 - methyl - N - propilpirrolo [2,1-f] [1,2,4] triazin - 6 - carboxamide with x-ray diffraction values expressed in 2 * such as 8.7; 12 1; 13.3 (+ / - 0.1), among others.A endothermy in the range of around 125 to 225u00bac; among other features. It also refers to the form of the N - 1 metansulfonico acid salt and form n-4 of the hydrochloric acid salt in the base.The procedure to produce Crystals of salts of the Free Base comprises the following steps: a) providing the Free Base or mixed Suspended in an organic Solvent such as tetrahydrofuran, N, n-dimethylformamide, Isopropyl alcohol,Among others; (b) reacting the Free Base with an aqueous solution of the acid which gives origin to the sa (c) The reaction Mixture with the acid salt Crystals of the Free Base and (d) to recover the acid salt in the form of crystals.It also relates to a Pharmaceutical composition, The Compound is an inhibitor of p38 kinase activity, which is useful in the treatment of rheumatoid arthritis
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