首页> 外国专利> compound, pharmaceutical composition, use of a compound, method for preventing, treating or ameliorating a disease or condition associated with unregulated angiogenesis, and methods for treating or ameliorating cancer, for reducing the metastatic potential of a tumor, and for treating or ameliorating tumors , and a condition or disease

compound, pharmaceutical composition, use of a compound, method for preventing, treating or ameliorating a disease or condition associated with unregulated angiogenesis, and methods for treating or ameliorating cancer, for reducing the metastatic potential of a tumor, and for treating or ameliorating tumors , and a condition or disease

机译：化合物，药物组合物，化合物的用途，预防，治疗或改善与血管生成失调有关的疾病或病状的方法，以及治疗或改善癌症，降低肿瘤的转移潜力以及治疗或改善肿瘤的方法，和状况或疾病

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"COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, METHOD TO PREVENT, TREAT OR IMPROVE A DISEASE-ASSOCIATED DISEASE ANGIOGENES, AND METHODS TO TREAT OR IMPROVE TORTURE, OR TO TROUGHT THE POTENTIAL TUMORS, AND A CONDITION OR DISEASE ". The invention relates to compounds of formula I, wherein D, E, F, G, W, YR ~ 1 ~, A, R ~ 9 ~, X, B, R ~ 8 ~ are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use alone or in combination with one or more other pharmaceutically active compounds in therapy, to treat disorders associated with dysregulated angiogenesis, such as cancer.

机译：“化合物，药物成分，化合物的使用，预防，治疗或改善疾病相关疾病血管瘤的方法，以及治疗或改善酷刑或对潜在肿瘤进行折磨的方法，以及状况或疾病”。本发明涉及式I的化合物，以及药学上可接受的盐，其中D，E，F，G，W，YR〜1〜，A，R〜9〜，X，B，R〜8〜如本文所定义。水合物或其溶剂化物，单独或与一种或多种其他药物活性化合物组合用于治疗，以治疗与血管生成失调有关的疾病，例如癌症。

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公开/公告号BRPI0417158A

专利类型
公开/公告日2007-03-06

原文格式PDF
申请/专利权人 LEO PHARMA A/S;
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申请/专利号BR2004PI17158
发明设计人 JEF FENSHOLDT;JACOB THORHAUGE;BJARNE NORREMARK;
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申请日2004-12-02
分类号C07C259/10;C07D213/84;C07D401/12;C07D413/06;A61K31/165;
国家 BR
入库时间 2022-08-21 20:59:26

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