首页> 外国专利> angiogenesis inhibitor molecule, use of an angiogenesis inhibitor molecule, therapeutic composition for cancer treatment, diagnostic composition for cancer diagnosis, use of antibody h33, produced by hybridoma 13h33, antibody fragment h33 as produced by hybridoma 13h33, and use of an h33 antibody fragment or derivative

angiogenesis inhibitor molecule, use of an angiogenesis inhibitor molecule, therapeutic composition for cancer treatment, diagnostic composition for cancer diagnosis, use of antibody h33, produced by hybridoma 13h33, antibody fragment h33 as produced by hybridoma 13h33, and use of an h33 antibody fragment or derivative

机译：血管生成抑制剂分子，血管生成抑制剂分子的用途，用于癌症治疗的治疗组合物，用于癌症诊断的诊断组合物，由杂交瘤13h33产生的抗体h33的使用，由杂交瘤13h33产生的抗体片段h33的使用以及h33抗体片段或衍生物

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摘要

"Molecule angiogenesis INHIBITORY, ONE OF USE molecule INHIBITORY angiogenesis, COMPOSITION therapy for cancer TREATMENT, COMPOSITION FOR DIAGNOSIS INTENDED FOR CANCER DIAGNOSIS, ANTIBODY USE H33, produced by hybridoma 13H33, FRAGMENT ANTIBODY H33 AS produced by hybridoma 13H33, H33 ANTIBODY DERIVATIVE PRODUCED BY 13H33 HYBRIDOMA, AND USE OF AN H33 ANTIBODY FRAGMENT OR DERIVATIVE ". The present invention relates to angiogenesis inhibiting molecules consisting of the H33 monoclonal antibody or fragments or derivatives thereof, relates to their use in the treatment of cancer, particularly in the treatment of solid tumors, and relates to therapeutic compositions and diagnostics that comprise these molecules. The invention relates particularly to humanized H33 derivatives or human monoclonal antibodies having the specificity of H33.

机译：“分子血管生成抑制，一种使用的分子抑制血管生成，用于癌症治疗的组合疗法，用于癌症诊断的诊断组合物，抗体使用H33，由杂交瘤13H33产生，片段抗体H33由杂交瘤13H33产生，由抗体33HDUC产生的抗体33H杂交，以及使用H33抗体片段或衍生物”。本发明涉及由H33单克隆抗体或其片段或衍生物组成的血管生成抑制分子，涉及其在癌症治疗中的用途，特别是在实体瘤的治疗中，并涉及包含这些分子的治疗组合物和诊断剂。本发明尤其涉及具有H33特异性的人源化H33衍生物或人单克隆抗体。

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公开/公告号BRPI0415541A

专利类型
公开/公告日2006-12-26

原文格式PDF
申请/专利权人 LABORATOIRES SERONO S.A.;
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申请/专利号BR2004PI15541
发明设计人 BEAT A. IMHOF;MICHEL AURRAND-LIONS;
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申请日2004-11-19
分类号G01N33/566;C07K16/28;C07K14/705;A61K38/17;A61K39/395;C12N5/20;
国家 BR
入库时间 2022-08-21 20:59:28

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