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Compositions, methods and kits for diagnosis and treatment of Chlamydia pneumoniae infections of the skin and those associated with cutaneous T-cell lymphoma

机译:诊断和治疗皮肤及与皮肤T细胞淋巴瘤相关的肺炎衣原体感染的组合物,方法和试剂盒

摘要

This invention provides methods of diagnosing and treating any C. pneumoniae infection of the skin including C. pneumoniae-associated diseases such as cutaneous T-cell lymphoma (CTCL), mycosis fungoides, Sézary syndrome, lymphomatoid papillosis, Ki-1 lymphoma, exfoliative exematous rash, and digitate parapsoriasis. This invention provides kits that are useful in the methods of the invention as well as for identifying new anti-chlamydial agents in treating skin infections. This invention includes a pharmaceutical vaccine composition comprising an antigen, including a full length antigenic determinant, such as any SAF positive determinant or portion thereof, which produces a detectable immune, humoral and/or cellular response to C. pneumoniae. The invention also includes a method of treating an active CTCL in a living being comprising delivering a therapeutically effective amount of a vaccine, wherein the vaccine comprises an agent, such as an inactivated C. pneumoniae material that produces a detectable immune, humoral and/or cellular response.
机译:本发明提供了诊断和治疗包括I C在内的皮肤的任何肺炎衣原体感染的方法。肺炎相关疾病,例如皮肤T细胞淋巴瘤(CTCL),真菌病,塞氏病,淋巴瘤样乳头状瘤,Ki-1淋巴瘤,剥脱性皮疹和手指状银屑病。本发明提供了可用于本发明方法以及用于鉴定用于治疗皮肤感染的新抗衣原体制剂的试剂盒。本发明包括一种药物疫苗组合物,其包含抗原,该抗原包括全长抗原决定簇,例如任何SAF阳性决定簇或其部分,该抗原对C产生可检测的免疫,体液和/或细胞应答。肺炎。本发明还包括一种治疗活的CTCL的方法,该方法包括递送治疗有效量的疫苗,其中所述疫苗包含试剂,例如灭活的IC。产生可检测的免疫,体液和/或细胞反应的肺炎材料。

著录项

  • 公开/公告号US7282343B1

    专利类型

  • 公开/公告日2007-10-16

    原文格式PDF

  • 申请/专利权人 J. TODD ABRAMS;BRIAN J. BALIN;

    申请/专利号US20010001067

  • 发明设计人 J. TODD ABRAMS;BRIAN J. BALIN;

    申请日2001-10-24

  • 分类号G01N33/567;A61K49/00;A61K39/00;

  • 国家 US

  • 入库时间 2022-08-21 21:03:37

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