首页> 外国专利> POLYNUCLEOTIDE ENCODING PROTEIN ASSOCIATED WITH APOPTOSIS OF HEPATIC STELLATE CELL, AND RIBOZYME SUPPRESSING ITS EXPRESSION

POLYNUCLEOTIDE ENCODING PROTEIN ASSOCIATED WITH APOPTOSIS OF HEPATIC STELLATE CELL, AND RIBOZYME SUPPRESSING ITS EXPRESSION

机译：编码多聚核苷酸的蛋白与肝星状细胞凋亡相关，并通过核酶抑制其表达

页面导航

摘要
著录项
相似文献

摘要

PPROBLEM TO BE SOLVED: To provide a polynucleotide encoding a protein associated with the apoptosis of hepatic stellate cells, and a ribozyme suppressing the expression of the same. PSOLUTION: The 20 clones of ribozyme sequences associated with the apoptosis of gliotoxin-induced hepatic stellate cells are obtained by using a gene discovery system with a randomized ribozyme library. By introducing a plasmid encoding Rz.1 sequence, which is one of the actually obtained clones, the cell obtains gliotoxin-induced apoptosis resistance. PCOPYRIGHT: (C)2007,JPO&INPIT

机译：<要解决的问题：提供编码与肝星状细胞凋亡相关的蛋白质的多核苷酸，以及抑制其表达的核酶。

解决方案：通过使用具有随机核酶文库的基因发现系统，获得了20种与胶质酶诱导的肝星状细胞凋亡相关的核酶序列的克隆。通过引入编码Rz.1序列的质粒，该序列是实际获得的克隆之一，该细胞获得了由胶质毒素诱导的凋亡抗性。

版权：（C）2007，日本特许厅＆INPIT 展开▼

著录项

公开/公告号JP2007037508A

专利类型
公开/公告日2007-02-15

原文格式PDF
申请/专利权人 JUNTENDO;GENOFUNCTION INC;
展开▼

申请/专利号JP20050227889
发明设计人 SATO NOBUHIRO;TAKEI KANEYUKI;
展开▼

申请日2005-08-05
分类号C12N15/09;A61K31/7088;A61K35/76;A61P1/16;A61P43;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N9;C12P21;C12N5/10;
国家 JP
入库时间 2022-08-21 21:14:12

相似文献

专利
外文文献
中文文献