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PYROGLUTAMIC ACID DERIVATIVES AND ASSOCIATED CONDITIONS, WHICH REDUCE THE LEUKOZYTE ACCESSION PRESENTED BY VLA-4
PYROGLUTAMIC ACID DERIVATIVES AND ASSOCIATED CONDITIONS, WHICH REDUCE THE LEUKOZYTE ACCESSION PRESENTED BY VLA-4
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机译：减少了VLA-4引起的白血病变应性的热葡萄糖酸衍生物和相关条件
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摘要
Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g. human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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