首页> 外国专利> Device useful to provide material e.g. medicine in first biological cells (target cells), comprising a first chamber to provide second biological cells, second chamber to provide particles and third chamber to mix second cells and particles

Device useful to provide material e.g. medicine in first biological cells (target cells), comprising a first chamber to provide second biological cells, second chamber to provide particles and third chamber to mix second cells and particles

机译:用于提供材料的装置,例如第一生物细胞(靶细胞)中的药物,包括提供第二生物细胞的第一室,提供颗粒的第二室和混合第二细胞和颗粒的第三室

摘要

Device (I), for providing or attaching a material in or to first biological cells (target cells), comprises a first chamber (1) for providing second biological cells, a second chamber (2) for providing particles, which are loaded with material which are to be transferred and are marked with an antibody, a third chamber (3) for mixing the second cells from the first chamber with the particles from the second chamber. Device (I), for providing or attaching a material in or to first biological cells (target cells), comprises a first chamber (1) for providing second biological cells, a second chamber (2) for providing particles, which are loaded with material which are transferred and are marked with an antibody, which specifically binds to a intracellular component of the second cells, a third chamber (3) for mixing the second cells from the first chamber with the particles from the second chamber, where the first chamber and the second chamber are connected over at least a fluid-permeable line (11a, 11b), and a outlet from the third chamber is arranged at a operatable valve (12a). An independent claim is also included for a method for providing or attaching a material in or to first biological cells (target cells), comprising mixing second biological cells and particles, which are loaded with the material to be transferred and marked with an anti-body, that specifically binds to a intracellular component of the second cells and incubated for a pre-determined time for at least partial supply of the particles into the cell interior of the second cells.
机译:用于在第一生物细胞(靶细胞)中或向其提供材料的装置(I)包括用于提供第二生物细胞的第一腔室(1),用于提供颗粒的第二腔室(2),该颗粒装有材料待转移的并带有抗体标记的第三腔室(3)将来自第一腔室的第二细胞与来自第二腔室的颗粒混合。用于在第一生物细胞(靶细胞)中或向其提供材料的装置(I)包括用于提供第二生物细胞的第一腔室(1),用于提供颗粒的第二腔室(2),该颗粒装有材料它们被转移并用与第二细胞的细胞内组分特异性结合的抗体标记,第三腔室(3)用于将来自第一腔室的第二细胞与来自第二腔室的颗粒混合,其中第一腔室和第二腔室至少通过流体可透过的管线(11a,11b)连接,并且第三腔室的出口布置在可操作阀(12a)处。还包括关于在第一生物细胞(靶细胞)中或向第一生物细胞(靶细胞)提供或附着材料的方法的独立权利要求,该方法包括将第二生物细胞和颗粒混合,所述第二生物细胞和颗粒负载有待转移的材料并标记有抗体。 ,其特异性结合第二细胞的细胞内组分,并孵育预定时间以至少部分地将颗粒供应到第二细胞的细胞内部。

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