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METHOD FOR INHIBITING LIPOPOLYSACCHARIDE-INDUCED PRODUCTION OF REACTIVE OXYGEN SPECIES AND ACTIVATION OF NF- B FROM ANIMAL CELL
METHOD FOR INHIBITING LIPOPOLYSACCHARIDE-INDUCED PRODUCTION OF REACTIVE OXYGEN SPECIES AND ACTIVATION OF NF- B FROM ANIMAL CELL
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机译：抑制脂多糖诱导的活性氧物种生产和动物细胞中NF-B活化的方法
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摘要
The invention lipopolysaccharide (lipopolysaccharide: LPS) in animal cells to a method of inhibiting the activation of NF-κB and generation of reactive oxygen species induced by. Creating and methods of inhibiting the activation of NF-κB in the active oxygen species induced by LPS in animal cells of the invention by introducing siRNA that can be complementarily bonded with Nox4 gene into a cell, for inhibiting the expression of Nox4 gene and a step. By being present according to the invention, it can inhibit the activation of NF-κB is known as gram-negative bacteria excessive generation of harmful reactive oxygen species induced by LPS and proinflammatory factor according to infection, widely in the treatment of inflammation in accordance with the bacterial infection It may be utilized.; Lipopolysaccharide (lipopolysaccharide: LPS), ROS (reactive oxygen species), Nox4, NF-κB
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