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METHODS FOR DIAGNOSING A BIPOLAR DISORDER AND ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
METHODS FOR DIAGNOSING A BIPOLAR DISORDER AND ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
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机译：诊断双歧疾病和注意力缺陷/多动障碍的方法
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摘要
Changes that occur in Na+K+ ATPase regulation and therefore in the membrane potential in cells from bipolar individuals, as compared to cells from unaffected control individuals, are utilized to provide a diagnostic assay for bipolar I and bipolar II disorders. The diagnostic assay may also or instead exploit the similarity of cells from new patients to those of people already known to have bipolar I or bipolar II disorder. A similar diagnostic assay is provided for diagnosing attention-deficit/hyperactivity disorder (ADHD) and unipolar disorder. The diagnostic assays may further involve manipulation of membrane potential by incubation of cells in K+-free buffer and/or incubation with one or more compounds that alter Na+K+ ATPase activity. Although a variety of cells may be used, the diagnostic assays preferably employ lymphoblasts or whole blood cells.
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机译：与来自未患病对照个体的细胞相比，来自双极个体的细胞中Na + K + ATPase调节以及因此膜电位中发生的变化被用于提供双极I型和双极II型疾病的诊断测定。诊断测定还可以或替代地利用新患者的细胞与已知患有双相性I型或双相性II型疾病的人的细胞相似性。提供了类似的诊断检测方法，用于诊断注意力缺陷/多动障碍（ADHD）和单相障碍。诊断测定还可包括通过在无K +缓冲液中孵育细胞和/或与改变Na + K + ATPase活性的一种或多种化合物孵育来操纵膜电位。尽管可以使用多种细胞，但是诊断测定法优选采用淋巴母细胞或全血细胞。
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