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SUBSTANCE INHIBITING THE BINDING OF SIGNAL TRANSDUCING MOLECULE TO KDR/FLK-1 PHOSPHORYLATED AT TYROSINE AT THE 1175-POSITION AND METHOD OF USING THE SAME
SUBSTANCE INHIBITING THE BINDING OF SIGNAL TRANSDUCING MOLECULE TO KDR/FLK-1 PHOSPHORYLATED AT TYROSINE AT THE 1175-POSITION AND METHOD OF USING THE SAME
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机译：在1175位上抑制信号转移分子与酪氨酸磷酸化的KDR / FLK-1结合的物质及其使用方法
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摘要
The present invention provides a substance which inhibits binding of a signal transduction molecule to 1175-tyrosine phosphorylated KDR/Flk-1 and inhibits cell growth by VEGF. Also, the present invention provides a method for inhibiting KDR/Flk-1 signal transduction, a method for inhibiting cell growth, a method for inhibiting angiogenesis, a method for screening a cell growth inhibitor, a method for screening an angiogenesis inhibitor, a method for screening a substance which inhibits KDR/Flk-1 signal transduction, a method for determining whether or not a tested substance can inhibit KDR/Flk-1 signal transduction, a method for detecting angiogenesis in tissue and a method for screening a substance which inhibits 1175-tyrosine phosphorylated. KDR/Flk-1, in which each method comprises using the substance.
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