首页> 外国专利> DETERMINATION OF THE 3D-STRUCTURE OF AN EXTRACELLULAR DOMAIN OF A B1 G-PROTEIN COUPLED RECEPTOR BY NMR ANALYSIS

DETERMINATION OF THE 3D-STRUCTURE OF AN EXTRACELLULAR DOMAIN OF A B1 G-PROTEIN COUPLED RECEPTOR BY NMR ANALYSIS

机译:NMR分析确定B1 G蛋白偶联受体胞外域的3D结构

摘要

The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present invention also relates to a method for improving antagonists or agonists of CRFR2. The present invention also relates to the three-dimensional structure of CRFR2 as representative of the B1 GPCR subfamily and its use as a basis for rational drug design of antagonist or agonists of B1 GPCRs.
机译:本发明涉及鉴定B1G蛋白偶联受体的调节剂的方法。本发明还涉及鉴定促肾上腺皮质激素释放因子受体2(CRFR2)的拮抗剂或激动剂的方法。本发明还涉及用于改善CRFR2的拮抗剂或激动剂的方法。本发明还涉及代表B1 GPCR亚家族的CRFR2的三维结构,以及其作为B1 GPCR拮抗剂或激动剂的合理药物设计基础的用途。

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