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Controlling offspring's sex ratio by targeting transgenes onto the sex chromosomes

机译：通过将转基因靶向性染色体来控制后代的性别比例

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摘要

A method for controlling the sex ratio of offspring by targeting transgenes is disclosed. The method involves: (a) selecting or creating a transgene whose expression can interfere with sperm's ability to undergo fertilization, and whose gene products (mRNA and protein) do not diffuse freely among inter-connected spermatids; (b) placing the transgene under the regulatory control of post-meiotic spermatogenesis-specific promoter; and (c) using the transgene to generate transgenic animals in the way that the transgene is inserted onto one of the two sex chromosomes.

机译：公开了一种通过靶向转基因来控制后代性别比例的方法。该方法涉及：（a）选择或创建一个其表达会干扰精子受精能力并且其基因产物（mRNA和蛋白质）不能在相互连接的精子中自由扩散的转基因; （b）将转基因置于减数分裂后精子发生特异性启动子的调控之下; （c）使用转基因以将转基因插入两个性染色体之一上的方式产生转基因动物。

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公开/公告号NZ520001A

专利类型
公开/公告日2005-12-23

原文格式PDF
申请/专利权人 CHENGYU LIU;
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申请/专利号NZ20000520001
发明设计人 COSTANTINI FRANKLIN;LIU CHENGYU;WANG JIN;
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申请日2000-12-27
分类号A01K67/00;A01K67/033;C12N5/00;C12N5/02;C12N15/00;C12N15/09;C12N15/63;C12N15/70;C12N15/74;C12N15/85;C12N15/87;
国家 NZ
入库时间 2022-08-21 21:38:06

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