首页> 外国专利> Process for making non-peg-treated long-circulating liposomes; liposome; non-pegylated long-term liposomal doxorubicin composition; and method

Process for making non-peg-treated long-circulating liposomes; liposome; non-pegylated long-term liposomal doxorubicin composition; and method

机译:制备未经钉处理的长循环脂质体的方法;脂质体非聚乙二醇化长期脂质阿霉素组合物;和方法

摘要

"PROCESS FOR MANUFACTURING LONG-CIRCULATION LIPOSOMAS NOT TREATED WITH PEG; LIPOSOME; COMPOSITION OF LONG-TERM LIPOSOMAL DOXORUBICIN TREATED WITH PEG; AND METHOD". The present invention provides a long-circulating non-PEG-treated liposomal doxorubicin composition for parenteral administration and a process for the preparation thereof. Circulation time in Swiss albino mice is at least 25 times longer than in conventional non-liposomal compositions. Non-PEG-treated liposomes are stable, exhibit low toxicity, and have been found to be effective in different tumor models.
机译:“制造未经PEG处理的长循环脂质体的方法;脂质体;经PEG处理的长期脂质体阿霉素的组成;和方法”。本发明提供了用于肠胃外给药的长循环的非PEG处理的脂质体阿霉素组合物及其制备方法。瑞士白化病小鼠的循环时间比传统的非脂质体组合物至少长25倍。未经PEG处理的脂质体稳定,毒性低,并且已发现在不同的肿瘤模型中有效。

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