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Process for making non-peg-treated long-circulating liposomes; liposome; non-pegylated long-term liposomal doxorubicin composition; and method
Process for making non-peg-treated long-circulating liposomes; liposome; non-pegylated long-term liposomal doxorubicin composition; and method
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机译:制备未经钉处理的长循环脂质体的方法;脂质体非聚乙二醇化长期脂质阿霉素组合物;和方法
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摘要
"PROCESS FOR MANUFACTURING LONG-CIRCULATION LIPOSOMAS NOT TREATED WITH PEG; LIPOSOME; COMPOSITION OF LONG-TERM LIPOSOMAL DOXORUBICIN TREATED WITH PEG; AND METHOD". The present invention provides a long-circulating non-PEG-treated liposomal doxorubicin composition for parenteral administration and a process for the preparation thereof. Circulation time in Swiss albino mice is at least 25 times longer than in conventional non-liposomal compositions. Non-PEG-treated liposomes are stable, exhibit low toxicity, and have been found to be effective in different tumor models.
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