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Methods of screening for compounds that inhibit expression of biomarker sequences differentially expressed with age in mice

机译:筛选可抑制小鼠年龄差异表达生物标志物序列表达的化合物的方法

摘要

A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment, the method comprises the steps of: (a) obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell, wherein the nucleic acid is RNA or a cDNA copy of RNA and (b) determining the gene expression pattern of at least one of the genes selected from the group consisting of M21050, Z49204, U49430, K02782, X58861, X66295, M22531, X67809, U19118, M64086, M63695, U39066, X92590, X56518, AA182189, X16493, U20344, X16834, X82648, D00754, D16313, L38971 and X15789.
机译:公开了一种测量多细胞生物的生物学年龄的方法。在一个实施方案中,该方法包括以下步骤:(a)获得从生物体的器官,组织或细胞分离的核酸样品,其中所述核酸是RNA或RNA的cDNA拷贝,和(b)确定基因表达选自M21050,Z49204,U49430,K02782,X58861,X66295,M22531,X67809,U19118,M64086,M63695,U39066,X92590,X56518,AA182189,X16493,U20344,X16834, X82648,D00754,D16313,L38971和X15789。

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