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Genetically engineered rabies recombinant vaccine for immunization of stray dogs and wildlife
Genetically engineered rabies recombinant vaccine for immunization of stray dogs and wildlife
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机译:转基因狂犬病重组疫苗,用于流浪狗和野生动物的免疫
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摘要
Live, attenuated recombinant rabies virus vaccines are generated using reverse genetics to combine the antigenic determinants that render the rabies virus non-pathogenic with the determinants that are responsible for the elicitation of an effective anti-rabies immune response. These vaccines do not affect the antigenic, and therefore the immunogenic, properties of the virus. The present invention further relates to recombinant rabies virus vaccines that express a pro-apoptotic protein, such as cytochrome c, to increase the capacity to induce apoptosis, thereby enhancing the protective immunity against rabies. This new generation of live rabies virus vaccines represents a safe and effective approach to the eradication of rabies in wildlife, and subsequently humans and livestock.
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