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Genetically engineered rabies recombinant vaccine for immunization of stray dogs and wildlife

机译:转基因狂犬病重组疫苗,用于流浪狗和野生动物的免疫

摘要

Live, attenuated recombinant rabies virus vaccines are generated using reverse genetics to combine the antigenic determinants that render the rabies virus non-pathogenic with the determinants that are responsible for the elicitation of an effective anti-rabies immune response. These vaccines do not affect the antigenic, and therefore the immunogenic, properties of the virus. The present invention further relates to recombinant rabies virus vaccines that express a pro-apoptotic protein, such as cytochrome c, to increase the capacity to induce apoptosis, thereby enhancing the protective immunity against rabies. This new generation of live rabies virus vaccines represents a safe and effective approach to the eradication of rabies in wildlife, and subsequently humans and livestock.
机译:使用反向遗传学产生活的减毒重组狂犬病毒疫苗,将使狂犬病病毒变为非致病性的抗原决定簇与负责引发有效抗狂犬病免疫应答的决定簇相结合。这些疫苗不影响病毒的抗原性和免疫原性。本发明进一步涉及重组狂犬病毒疫苗,其表达促凋亡蛋白,例如细胞色素c,以增加诱导凋亡的能力,从而增强针对狂犬病的保护性免疫。新一代的狂犬病活疫苗代表了一种安全有效的方法,用于消灭野生动植物以及随后的人类和牲畜中的狂犬病。

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