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METHOD FOR DETERMINING ANTICANCER CHARACTERISTIC OF ANTICANCER AGENT AGAINST NON SMALL CELL LUNG CANCER

机译:确定抗小细胞肺癌抗癌药抗癌药特性的方法

摘要

PROBLEM TO BE SOLVED: To provide a judging method by which an anticancer agent usable for therapy of non small cell lung cancer and taking effects on a patient.;SOLUTION: The method for determining the characteristics of the anticancer agent comprises getting the interrelation between an expression amount of a ganglioside GM3 synthetase gene (SAT-I) of a cell of the non small cell lung cancer and anticancer effects of the anticancer agent. When the characteristics of the anticancer agent is determined thus, it is expected that the useless administration of the anticancer agent is evaded, the side effects are reduced and the treatment takes effects by determining the amount of SAT-I mRNA in the cancer cell of the patient suffering from the non small cell lung cancer, and administering the anticancer agent with inhibition activities, having negative interrelation when the expression rate is high, or administering the anticancer agent having positive interrelation when the expression rate is low.;COPYRIGHT: (C)2006,JPO&NCIPI
机译:要解决的问题:提供一种判断方法,通过该方法可以将抗癌剂用于治疗非小细胞肺癌并对患者产生影响。解决方案:确定抗癌剂特性的方法包括:非小细胞肺癌细胞中神经节苷脂GM3合成酶基因(SAT-1)的表达量和抗癌剂的抗癌作用。因此,当确定抗癌剂的特性时,可以避免无用的抗癌剂给药,减少副作用,并且通过确定癌细胞癌细胞中SAT-1 mRNA的量来进行治疗。非小细胞肺癌患者,表达率高时给药具有抑制活性的抗癌药物,表达率低时给药具有负相关的药物; COPYRIGHT:(C) 2006年,日本特许厅

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