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首页> 外国专利> Adenoviral vector encoding modified capsid protein, useful in gene therapy of e.g. cancer and cystic fibrosis, can infect cells deficient in, or lacking, the common receptor for Coxsackie virus B3 and adenovirus

Adenoviral vector encoding modified capsid protein, useful in gene therapy of e.g. cancer and cystic fibrosis, can infect cells deficient in, or lacking, the common receptor for Coxsackie virus B3 and adenovirus

机译：编码修饰的衣壳蛋白的腺病毒载体，可用于例如癌症和囊性纤维化可感染缺乏或缺乏柯萨奇B3和腺病毒共同受体的细胞

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Adenoviral vector (A) for expressing a DNA sequence (I) in mammalian cells contains, in at least one DNA (II) that encodes regions of low structural constraint in a capsid protein, at least one sequence (III) that encodes a heterologous peptide (IIIa) containing the motif -(Trp/Arg)-X1-X2-Asp. Independent claims are also included for the following: (1) method for in vitro preparation of infectious adenoviral particles (AVP) in producer cells by transfecting these cells with (A); (2) AVP prepared by method (1); (3) method for modifying the tropism of an adenoviral vector by inserting at least one (III) into at least one (II); (4) in vitro method for preferentially expressing a (I) in mammalian target cells by contacting the cell with AVP of (1) or with (A); and (5) mammalian cells transformed with (A). ACTIVITY : Cytostatic. No details of tests for cytostatic activity. MECHANISM OF ACTION : Gene therapy.
机译：用于在哺乳动物细胞中表达DNA序列（I）的腺病毒载体（A）在至少一个编码衣壳蛋白中低结构限制区域的DNA（II）中包含至少一个编码异源肽的序列（III） （IIIa）含有基序-（Trp / Arg）-X1-X2-Asp。还包括以下方面的独立权利要求：（1）通过用（A）转染这些细胞在生产细胞中体外制备传染性腺病毒颗粒（AVP）的方法; （2）通过方法（1）制备的AVP; （3）通过将至少一种（III）插入至少一种（II）来改变腺病毒载体的向性的方法; （4）通过使细胞与（1）的AVP或（A）接触而在哺乳动物靶细胞中优先表达（I）的体外方法; （5）用（A）转化的哺乳动物细胞。活动：细胞静息。没有详细的细胞抑制活性测试。作用机理：基因治疗。

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