The present invention is related to a transgenic animal showing Alzheimer's disease pathology. More particularly, the present invention provides a transgenic vector comprising a mutant human beta amyloid precursor protein whith Swedish double mutation and Indiana mutation simultaneously, and a transgenic mouse showing Alzheimer's disease generated by microinjection of the above vector into a pronuclei of a fertilized oocyte followed by generating mice. The transgenic mouse of the present invention exhibited clnicical symptoms of Alzheimer's disease, such as decreases of cognitive ability and memory, and increases of anxiety. Therefore, the transgenic mouse of the present invention will be a useful animal model for a research of Alzheimer's disease. Particularly, because the transgenic mouse of the present invention showed more profound increase of anxiety than any other transgenic animal model for Alzheimer's disease known in the art, the transgenic mouse of the present invention can be used as an animal model for anxiety-related disorders.
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