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TRANSGENIC CELLS TRANSFECTED WITH PITUITARY TUMOR TRANSFORMING GENE (PTTG) EXPRESSION VECTORS AND USES THEREFOR
TRANSGENIC CELLS TRANSFECTED WITH PITUITARY TUMOR TRANSFORMING GENE (PTTG) EXPRESSION VECTORS AND USES THEREFOR
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机译：垂体瘤转化基因（PTTG）表达载体转化的转基因细胞及其用途
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摘要
Polypeptides are expressed by the pituitary-tumor-transforming-gene (PTTG), formerly known as pituitary-tumor-specific-gene (PTSG), and nucleic acids encoding them. Examples are the human and rat PTTG proteins. The nucleic acids may be applied to the production of a recombinant protein, and to the detection of the presence of PTTG genes in different species. The nucleic acids may be operatively linked to a vector, optionally provided with control and expression sequences and/or being carried by a host cell. The nucleic acids may also be delivered to a mammal to compensate for the absence, or a defective expression, of endogenous protein. The nucleic acids, proteins, and antibodies are also employed in diagnostic assays, as well as, for example, in the production of anti-PTTG antibodies (protein), therapeutic compositions and other applications of the proteins and antibodies. Various kits utilize nucleic acids, polypeptides, and/or antibodies. A transgenic non-human mammal expresses PTTG.
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