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DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED APELIN RECEPTOR (APJ)
DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED APELIN RECEPTOR (APJ)
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机译:与G蛋白偶联的APELIN受体(APJ)相关的疾病的诊断和治疗
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摘要
The invention provides a human APJ which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, hematological disorders, respiratory diseases, muscle-skeleton disorders, neurological disorders, urological disorders, dermatological diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, hematological disorders, respiratory diseases, muscle-skeleton disorders, neurological disorders, urological disorders, dermatological diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of APJ as well as pharmaceutical compositions comprising such compounds.
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