It refers to a compound composed of a molecule connected to CD20, with a binding degree of 5.0 × 10-10 m or less for CD20 human and a dispersion rate of 5.0 × 10-10 S-1 or less for CD20 human. This molecule includes: (a) a variable chain region consisting of (1) a series of CDR1 amino acids, such as: sec No. 1, SEC No. 3 and SEC No. 5; (2) a series of CDR2 amino acids, such as SEC No. 7, SEC No. 9, SEC No. 11 and SEC No. 13; and (3) a series of CDR3 amino acids, such as SEC No. 17.Ibid., section 19 and ibid., section 21. (b) The second group of nucleic acids encodes a variable heavy chain region, including: (1) a series of CDR1 amino acids, such as SEC ID No.23 and SEC ID No.25; (2) a series of CDR2 amino acids, such as SEC ID No.27, SEC ID No.29, SEC ID No.31, SEC ID No.33, Sec ID No.35, SEC ID No.37 and SEC ID No.39; Y (3) a series of CDR3 carbamates, such as SEC ID No.43, SEC ID No.45, SEC ID No.47, SEC ID No.49, SEC ID No.51, SEC ID No.53, SEC ID No.55,Ibid., section 57. Also mentioned is the nucleic acid sequence encoding the linker into CD20, including the use of a fully human structural chain in cell B-lymphoma treatment.
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机译：它是指由与CD20连接的分子组成的化合物，其对CD20人的结合度为5.0×10-10 m或更小，对CD20人的分散率为5.0×10-10 S-1或更小。该分子包括：（a）由（1）一系列CDR1氨基酸组成的可变链区，例如：第1、2、3号和5号SEC; （2）一系列CDR2氨基酸，例如SEC No. 7，SEC No.9，SEC No.11和SEC No.13; （3）一系列CDR3氨基酸，例如SEC No.17，同上，第19部分和同上，第21部分。（b）第二组核酸编码可变重链区，包括：（1 ）一系列CDR1氨基酸，例如SEC ID No.23和SEC ID No.25; （2）一系列CDR2氨基酸，例如SEC ID No.27，SEC ID No.29，SEC ID No.31，SEC ID No.33，Sec ID No.35，SEC ID No.37和SEC ID 39号Y（3）一系列CDR3氨基甲酸酯，例如SEC ID号43，SEC ID号45，SEC ID号47，SEC ID号49，SEC ID号51，SEC ID号53，SEC ID No.55，同上，第57节。还提到了编码进入CD20的接头的核酸序列，包括在细胞B淋巴瘤治疗中使用完整的人结构链。
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