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Reaction mixture for determining hemoglobin in a blood sample and method for the determination of hemoglobin using a whole blood sample
Reaction mixture for determining hemoglobin in a blood sample and method for the determination of hemoglobin using a whole blood sample
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机译:用于测定血样中血红蛋白的反应混合物以及使用全血样品测定血红蛋白的方法
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摘要
In the present invention, there is described a reagent composition for the determination of hemoglobin in a blood sample, comprising in aqueous admixture at least one surfactant in an amount effective to hemolyze red blood cells in said sample and form micelles; a soluble inorganic cyanide salt in an amount effective to bind to heme molecules resulting from said blood cell hemolysis; and a pH buffer capable of maintaining a pH of said reagent composition at about 10.0 to about 11.2; wherein said reagent composition in admixture with said blood sample provides freedom from white blood cell interference in automated hemoglobin detection methods. Further disclosed is a method for determining hemoglobin in a whole blood sample, said method comprising: a) mixing an aliquot of said blood sample with the above-described reagent composition to form a reaction mixture; and b) analyzing said reaction mixture on an automated hematology analyzer instrument to determine hemoglobin using the above-indicated reagent composition.
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