首页> 外国专利> Isolated or recombinant nucleic acid molecule, isolated polypeptide, nucleic acid construction, methods of modifying a parental polyketide synthase, modifying a parental borrelidine polyketide synthase, enhancing the ability of a host cell to produce borrelidine, or a borrelidine derivative or analog in a host cell, of modifying a host cell, of producing a modified borrelidine polyketide or derivative thereof in a host cell and synthesis of polyketide, vector, host cell, and, compound

Isolated or recombinant nucleic acid molecule, isolated polypeptide, nucleic acid construction, methods of modifying a parental polyketide synthase, modifying a parental borrelidine polyketide synthase, enhancing the ability of a host cell to produce borrelidine, or a borrelidine derivative or analog in a host cell, of modifying a host cell, of producing a modified borrelidine polyketide or derivative thereof in a host cell and synthesis of polyketide, vector, host cell, and, compound

机译:分离的或重组的核酸分子,分离的多肽,核酸结构,修饰亲本聚酮化合物合酶,修饰亲本硼联吡啶聚酮化合物合酶,增强宿主细胞在宿主细胞中产生硼联吡啶或硼联吡啶衍生物或类似物的能力的方法,修饰宿主细胞,在宿主细胞中产生修饰的硼瑞啶聚酮化合物或其衍生物,以及聚酮化合物,载体,宿主细胞和化合物的合成

摘要

"INSULATED OR RECOMBINING NUCLEID ACID POLYCLE, DEVELOPMENT OF POLYETHYL, DEVELOPMENT OF POLYETHYL, DYNAMIC POLYCLEID, PROCEDURAL POLYETHYL, POLYETHYL POLYETHYL BORRELIDINE OR ANALOG IN A HOST CELL, MODIFYING A HOST CELL, PRODUCING A MODIFIED POLYCETIDE OF BORRELIDINE OR ITS DERIVED IN A HOST CELL, SYNTHESIS AND VECTOR CELLS, The present invention relates to the biosynthesis of polyketides and derivatives by cloning nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of borrelidine polyketide. Materials and methods are provided including enzyme systems, nucleic acids, vectors and cells for the preparation of polyketides, including borrelidine and its analogs and derivatives. Unpublished polyketide molecules are also provided.
机译:“在宿主细胞中绝缘或重组了核酸聚合物,聚乙烯的发展,聚乙烯的发展,动态聚合物的发展,过程性的聚乙烯,聚乙烯基的聚乙烯基硼赖氨酸或类似物的修饰,修饰了一个存储的细胞,将其降解成酸性的原因是: ,合成和载体细胞,本发明涉及通过克隆编码聚酮化合物合酶的核酸和参与硼瑞啶聚酮化合物合成的其他相关蛋白的生物合成聚酮化合物和衍生物,提供了包括酶系统,核酸,载体的材料和方法。还提供了用于制备聚酮化合物的细胞,包括硼瑞定及其类似物和衍生物,还提供了未公开的聚酮化合物分子。

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