首页> 外国专利> Methods of treating or preventing and controlling a myeloproliferative disease, reducing or preventing an adverse effect associated with the administration of a second active agent in a patient suffering from a myeloproliferative disease, and enhancing the therapeutic efficacy of a myeloproliferative disease treatment, composition. pharmaceutical and kit

Methods of treating or preventing and controlling a myeloproliferative disease, reducing or preventing an adverse effect associated with the administration of a second active agent in a patient suffering from a myeloproliferative disease, and enhancing the therapeutic efficacy of a myeloproliferative disease treatment, composition. pharmaceutical and kit

机译：在患有骨髓增生性疾病的患者中治疗或预防和控制骨髓增生性疾病，减少或预防与施用第二种活性剂相关的不利影响，以及增强骨髓增生性疾病治疗组合物的治疗功效的方法。药品和试剂盒

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摘要

"METHODS OF TREATING OR PREVENTING AND CONTROLING A MYELOPROLIFERATIVE DISEASE, REDUCING OR AVOIDING AN ADVERSE EFFECT ASSOCIATED WITH ADMINISTRATION OF A SECOND ACTIVE PATIENT OF A MILEOPROATIERATIVE DEVELOPMENTAL MYELOPROATIAL DISEASE PHARMACEUTICAL COMPOSITION AND KIT ". Methods of treating, preventing and / or controlling a myeloproliferative disease are described. Specific methods include administering a selective cytokine inhibitory drug, or a solvate salt, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and / or blood transplantation or of cells. The second specific active agent is capable of suppressing hematopoietic stem cell overproduction or ameliorating one or more of the symptoms of MPD. Pharmaceutical compositions, individual unit dosage forms, and kits suitable for use in methods of the invention are also described.

机译：“治疗或预防和控制骨髓增生性疾病，减少或避免与不良反应有关的第二次活动的患者，该患者的第二次活动是由于前列腺肥大性骨髓增生性疾病的药物成分和药盒的管理。”描述了治疗，预防和/或控制骨髓增生性疾病的方法。具体方法包括单独或与第二活性剂组合施用选择性细胞因子抑制药或其溶剂化物盐，水合物，立体异构体，包合物或前药，和/或血液移植或细胞。第二种特异性活性剂能够抑制造血干细胞过度生产或减轻MPD的一种或多种症状。还描述了适用于本发明方法的药物组合物，单个单位剂型和试剂盒。

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公开/公告号BR0316002A

专利类型
公开/公告日2005-09-13

原文格式PDF
申请/专利权人 CELGENE CORPORATION;
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申请/专利号BR20030316002
发明设计人 JEROME B. ZELDIS;
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申请日2003-04-13
分类号C07D209/34;A61K38/21;A61K38/19;
国家 BR
入库时间 2022-08-21 22:18:33

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